College of Health Sciences
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Item FERTILITY DESIRE AND ITS ASSOCIATED FACTORS AMONG WOMEN ATTENDING ANTIRETROVIRAL THERAPY AT PUBLIC HOSPITALS IN MEKELLE, TIGRAY, ETHIOPIA, 2024: CROSS SECTIONAL STUDY(Mekelle University, 2025-02-25) SOLOMON TEKLUBackground: Fertility desire is defined as having motivation or intention to give birth by individuals in their future life irrespective the number of children. Fertility desire has undesirable effect on the transmission of human immunodeficiency virus to the partner due to unsafe sex, vertical transmission to the children and there will be also disagreement with the strategies developed for elimination of human immunodeficiency virus/acquired immunodeficiency syndrome in countries including Ethiopia. Objective: To assess the prevalence of fertility desire and its associated factors among women attending antiretroviral therapy at public hospitals in Mekelle, Tigray, Ethiopia, 2024. Methods and Materials: Institutional based cross-sectional study was conducted among 355 women and participants were selected using systematic random sampling method. The data were collected from August 1, 2024 to August 30, 2024 using pre-tested and interviewer administer questionnaire. Few variables were recorded from participant’s card. The data were analyzed using statistical package for social science version 27. Binary logistic regression method of analysis was used. All variables with P-value <0.25 in bivariate were included in the multivariable binary logistic regression analysis. The strength of the association was interpreted using an adjusted odds ratio with its 95% confidence interval. Statistically significant variable was declared at P-value < 0.05. Finally, the data were presented with texts, tables, figures, and graphs. Results: This study included 355 women, of them 345(97.2%) responded to the study. The prevalence of fertility desire was 182(52.8%, 95% CI: 46.6%-59.1%). Being single 69.3% (AOR: 0.307, 95% CI: O.111-0.84), being widowed 91% (AOR: 0.09, 95% CI: 0.038-0.214), being divorced 76.7% (AOR: 0.233, 95% CI: 0.109-0.497), number of women’s child 50.8% (AOR: 0.492, 95% CI: 0.382-0.632) and knowledge of women on prevention mother to child transmission 24.5% (AOR: 0.755, 95% CI: 0.608-0.938) were negatively associated with fertility desire. Conclusion and recommendation: This study revealed that more than half of participants had fertility desire and factors associated with it were marital status, number of women’s child, knowledge of the women on prevention mother to child transmission. All stakeholders should take into account the prevalence of fertility and its associated factors while serving the women living with human immunodeficiency virus and counsel the women to decrease their interest on the number of children and promote knowledge on the prevention of mother to child transmission.Item MAGNITUDE AND ASSOCIATED FACTORS OF TB/HIV CO INFECTION AMONG HIV INFECTED PATIENTS ATTENDING IN MEKELLE PUBLIC HOSPITALS, TIGRAY, ETHIOPIA 2024/25(Mekelle University, 2025-05-21) KAHSU TSEGAYIntroduction: -Tuberculosis is a contagious air born disease caused by Mycobacterium tuberculosis species and the leading causes of morbidity and mortality among people living with HIV/AIDS worldwide accounting for about 25% of all causes of the deaths. HIV infected clients are more susceptible to Tuberculosis infection. The World Health Organization Global Tuberculosis report of 2018 estimated that 10.0 million new cases of Tuberculosis occurred in 2017, of which over 82% of Tuberculosis deaths occurred in low- and middle-income countries. Evidence from this study helps to develop policies that address TB and HIV in an integrated, cost-effective manner and more efficient use of funds and resources. Objective: - The aim of this study was to assess the Magnitude and its associated factors of TB/ HIV co-infection among HIV infected patients in public hospitals of Mekelle, Tigray, Ethiopia 2025. Methods and materials: - Institutional based cross-sectional study was conducted and the period of data collection was from November to December 2024 G.C among ART patients. Systematic sampling technique was used to select 394 participants from the total source population. Data were collected using a pretested, interviewer, administered questionnaire and reviewing the medical record of the patient (CD4 cell count, hemoglobin level, BMI, WHO clinical stage, diagnosis of opportunistic infections, and TB). Data collection tool was pretested in 5% of total sample size in Wukro General Hospital. Data were coded and entered in to Epi data and was exported to statistical package for social science version 27 for statistical analysis. Descriptive statistics were performed. Both bivariate and multivariable logistic regression analyses were used to determine the association between independent variable and dependent variable. Variables having p value less than 0.25 in the bivariate analysis were exported in to multivariate logistic regression in multivariate logistic regression, p value <0.05 with 95% confidence interval (CI) was considered statistically significant. The Hosmer- Lemeshow goodness-of-fit model coefficients tests procedure was used to test for model fitting. Result – The magnitude of TB/ HIV co-infection was 18.8% and confidence interval (18.761 – 18.839). Marital status being widowed (AOR and 95% CI 0.238 (0.062, 0.903), hemoglobin level less than 11 (AOR and 95% CI 4.937 (1.884, 12.943), low CD4 count (200 cells mm3) (AOR and 95% CI 3.405 (1.174, 9.872), suspected TB patients in the household AOR and 95% CI 2.59 (1.026, 6.562) opportunistic infection without TB AOR and 95% CI (6.169 (2.272, 16.747), ambulatory AOR and 95% CI 22.906 (4.918,106.697), Bedridden AOR and 95% CI 11.436 (3.461, 37.79), poor drug adherence AOR and 95% CI 3.767 (1.389, 10.221), alcohol consumption AOR and 95% CI 15.129 (5.232, 43.748), raw/un cook foods consumption AOR and 95% CI 3.255 1.094, 9.682. were significant determinants of TB/HIV co-infection among HIV clients. Conclusion and recommendation The prevalence of tuberculosis among ART patients was high and this study indicated that marital status, hemoglobin level, CD4 count, presence of suspected TB patients in the household, presence of opportunistic infection without TB, functional status, drug adherence, alcohol consumption, utilization of raw/un cook foods were found significantly associated with TB/HIV co-infection. Providing counseling and health education regarding drug adherence, alcohol consumption and chat chewing to ART patients, and government should give priority on TB/ HIV confection.Item DETERMINANTS OF LATE INITIATION OF ANTENATAL CARE CONTACT AMONG PREGNANT WOMEN IN HEALTH FACILITIES OF MEKELLE, TIGRAY, NORTHERN ETHIOPIA, 2024(Mekelle University, 2025-02-25) GENET TESFAMICHAELBackground: Late antenatal care is the most common issue in developing countries, including Ethiopia. In Ethiopia, 72% of pregnant women come late for their first antenatal care contact. Late antenatal care initiation is more likely to be linked to poor perinatal health outcomes. Where the effects of late antenatal care initiation are significant in Ethiopia, a scarcity of data hinders for understanding of its determinants. Objective: To identify determinants of late initiation of antenatal care contact among pregnant women in health facilities of Mekelle, Tigray, Northern Ethiopia,2024. Method: Facility based unmatched case control study was conducted in health facilities of Mekelle, Tigray, Northern Ethiopia, from 7 August -5 September, 2024. The data were collected using pre-tested structured questionnaire. In this study 592 study participants (296 cases and 296 controls) were selected using systematic random sampling technique. Cases to controls ratio was 1 to 1. Bivariate and multivariable logistic regression analysis were used to identify determinants of late antenatal care initiation and adjusted odds ratio with corresponding 95% confidence interval was used to measure strength of association. Statistical significance was declared at 𝑃-value <0.05. Result: A total of 592 study participants were included in the study with 98% response rate. Low educational level [AOR=5.60;95%CI:2.766-11.357], recognizing pregnancy by missed period [AOR=2.552; 95%CI:1.588-4.102], unplanned pregnancy [AOR=3.216; 95%CI:1.934-5.347], not accompanied by their husband to ANC contact [AOR=4.306; 95%CI:2.757-6.726] and poor knowledge of the mothers about ANC [AOR=2.049; 95%CI: 1.326-3.168] were identified as determinants of late initiation of ANC among pregnant women. Conclusion and recommendation: Low educational level, recognizing pregnancy by missed period, unplanned pregnancy, not accompanied by their husband to ANC contact and poor knowledge of the mothers about ANC were identified as determinants of late initiation of ANC among pregnant women. Therefore, Health offices and healthcare providers should focus on increasing awareness to improve women's knowledge on ANC services, and to support spouse involvement in ANC.Item MAGNITUDE AND ASSOCIATED FACTORS OF ANTISOCIAL PERSONALITY DISORDER AMONG PRISONERS AT MEKELLE CORRECTIONAL CENTER, TIGRAY, ETHIOPIA, 2024/2(Mekelle University, 2025-02-25) BRHANU MERESABackground: Antisocial personality disorder is characterized by a consistent pattern of disregard for and violating the rights of others, this condition starts in childhood or early adolescence and into adulthood. Families, relationships, and social functioning are all significantly impacted, and individuals with ASPD place a significant burden on the legal system as well as social and mental health agencies. Despite the fact that ASPD is a prevalent issue among prisoners, little research has been done on it in Ethiopia and there has not been any published research on the subject in Tigray. Objective: To assess the prevalence and associated factors of antisocial personality disorder among prisoners at Mekelle correctional center, Mekelle, Tigray, Ethiopia, 2024. Methods: A cross-sectional study was conducted at Mekelle Correctional Center with 353 participants selected through systematic random sampling. Antisocial personality disorder was assessed by the Diagnostic and Statistical Manual of Mental Disorders 5th text revision and an interviewer-administered questionnaire. Data analysis was performed using SPSS Version 27, applying bivariate and multivariable logistic regressions were done to identify factors related to antisocial personality disorder. Significant predictors of antisocial personality disorder were identified with p-values below 0.05 at a 95% confidence interval and the data ware presented using text, tables and graphs. Result: A total of 353 participants were included in the study, with a response rate of 98.33%. The prevalence of antisocial personality disorder among prisoners was found to be 23.8%, with a 95% CI of (19.4, 28.6). This study found statistically significant associations between antisocial personality disorder and history of mental illness (AOR = 2.79, 95% CI: 1.15, 6.81), previous incarceration (AOR = 3.30, 95% CI: 1.33, 8.22), poor social support (AOR = 3.72, 95% CI: 1.63, 8.49), and adverse childhood experiences (AOR = 4.68, 95% CI: 1.38, 15.80). Conclusion: According to this study about one-quarter of the participants were found to have an anti-social personality disorder antisocial personality disorder among prisoners. History of mental illness, previous incarceration, poor social support, and adverse childhood experiences(s) were factors statistically associated with antisocial personality disorder. Addressing these factors could help reduce antisocial personality disorder prevalence and improve the mental health of the incarcerated population.Item UNINTENDED PREGNANCY AND ASSOCIATED FACTORS AMONG PREGNANT WOMEN ATTENDING ANTENATAL CARE IN MEKELLE CITY PUBLIC HEALTH FACILITIES, TIGRAY REGION, ETHIOPIA, 2025(Mekelle University, 2025-04-28) TSEGA WELEGEBRIALUnintended pregnancy is an important public health problem for women of child - bearing age, because of its negative impacts on health and social for both mothers and children. Unintended pregnancy causes maternal mortality and morbidity. Worldwide, although unplanned pregnancies seem to be decreasing, 38% of pregnancies are unintended. In sub-Saharan Africa, unintended pregnancy accounts for more than a quarter of the 40 million pregnancies that occur annually. In Ethiopia, about 17% and 8% of pregnancies are mistimed and unwanted, respectively. But, there is lack of information particularity post-conflict recovery in the study area on the prevalence of unintended pregnancy and its associated factors. To assess the prevalence and associated factors of unintended pregnancy among pregnant women attending antenatal care in Mekelle City Public Health Facility, Tigray region, Ethiopia, 2025. A facility-based cross-sectional study was conducted among 394 Pregnant women attending ANC in Mekelle City Public Health Facility. A simple random sampling technique was used to select study health facilities and a systematic random sampling technique was used to select study participants. Data was collected via face-to-face interview using a structured questionnaire. Data were entered into SPSS version 25 for analysis. Descriptive, bivariate, and multivariate logistic regression analyzes were used to identify the association. Variables that showed a P-value of less than 0.25 during the bivariate analysis were used and were entered into a multivariate logistic regression model to identify their independent effects. Odds ratio with a 95% CI & p value of less than 0.05 were computed to assess the presence and degree of statistical association between dependent and independent variables. The overall magnitude of unintended pregnancy was 32.7% with 95% CI (27.9, 38.1). Of those, 89.1% were mistimed and 10.9% were unwanted. The multiple logistic regression results revealed that, age group from 15 to 24 (AOR=4.702,95% CI 1.948,11.348). The women and husband’s decision in the family planning (AOR=0.292,95% CI 0.155,0.551), family size of 3-5(AOR=2.730,95%CI 1.512,4.930) and family size of≥6(AOR=3.967,95%CI 1.228,12.817), no formal education (AOR=3.336, 95%CI 1.340,8.308) were significantly associated with unintended pregnancy. There is no single factor accounted for the relatively high of unintended pregnancy rather many factors were interwoven to affect the event. Efforts should be made to scale up shared decision-making power in family planning services and there is the need to promote family planning services and awareness to minimize unintended pregnancy.Item Assessment of Schistosoma mansoni Infection and Associated Risk Factors Among Elementary School Children in Gembella and Feleg-Daero, Mekelle City, Ethiopia(Mekelle University, 2025-04-25) Abeba TekluSchistosomiasis is a widespread parasitic infection transmitted through contact with contaminated water, posing a major global public health challenge, particularly in developing countries. It affects individuals of all ages, with children being among the most vulnerable. Identifying the prevalence, associated risk factors, and high-risk populations is crucial for designing and implementing effective prevention and control strategies. This study aimed to assess Schistosoma mansoni infection and the associated risk factors among elementary school children in Gembella and Feleg-Daero (Adis Alem) elementary schools, in Mekelle City, Ethiopia. A cross-sectional study was conducted from January to September 2024, employing a purposive sampling technique to select schoolchildren. A total of 308 stool samples collected from elementary school children aged 7 to 20 years were examined using the wet mount and Kato-Katz techniques. A pre-tested questionnaire was utilized to gather socio-demographic information and associated risk factors. The data was coded, entered, and analyzed using descriptive statistics, bivariate and multivariate logistic regression and the significance level was set at p < 0.05 with 95% confidence interval. The overall prevalence of Schistosoma mansoni infection was 51.0% (157/308), with a median infection intensity of 192 eggs per gram of stool (EPG) among infected individuals. Among the infected children, 26.1%, 49.7% and 24.2% had light, moderate and heavy infections respectively. Significant risk factors for Schistosoma mansoni infection included swimming (AOR: 4.89; 95% CI:1.35, 17.75, P<0.001), washing clothes in rivers or streams (AOR:3.72; 95% CI: 1.12,12.37, P<0.001), engaging in irrigation activities (AOR:1.03;95%CI: 0.28,3.77, P<0.022), and bathing in river (AOR: 2.19,95% CI, 0.17-28.76, P< 0.001) and water contacts with flowing river (AOR:1.41; 95%CI: 0.23, 8.50, P<0.001). Schistosoma mansoni infection among children in this study was alarmingly high, with nearly half of the infected cases classified as having moderate intensity. These findings underscore the urgent need for targeted interventions, including health education, improved access to safe water, and regular deworming programs, to effectively reduce the disease burden and its associated risks.