College of Health Sciences
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Item Sero-prevalence and Predictors of Syphilis and HIV Co-infection among pregnant women attending ANC in Mekelle City of Conflict-Affected Tigray Region, Ethiopia: Evidence from Firth Penalized Regression(Mekelle University, 2024-11-21) SENAIT HADDISBackground: Sexually transmitted infections (STIs), particularly syphilis and HIV, significantly impact pregnant women in resource-limited countries, complicating treatment and increasing maternal and neonatal risks. In Mekelle City, Tigray, Ethiopia, barriers including limited antenatal care (ANC) access, physiological vulnerability, behavioral risks, socio-economic constraints, and conflict further exacerbate the burden of these infections, underscoring the critical need for accurate prevalence data and identification of predictive factors. Objective: This study aimed to determine the sero-prevalence of HIV/syphilis co-infection and identify associated predictors among pregnant women attending ANC in Mekelle City. Method: A facility-based cross-sectional study was conducted among pregnant women attending ANC services in selected health facilities across Mekelle City, Tigray, Ethiopia. A two-stage stratified sampling procedure was utilized to draw representative pregnant women under ANC from a health facility in each sub city. Data collection involved an interview-administered questionnaire and pregnant women’s registration books. Due to the relatively small sample size and rarity of co-infection events, Firth penalized logistic regression was employed for statistical analysis to mitigate bias and ensure model stability. Adjusted odds ratios (AOR) with 95% confidence intervals (CI) were computed to identify significant predictors. Result: Out of 438 pregnant women enrolled, the sero-prevalence of HIVsyphilis co-infection was 3.7% (95% CI: 1.87–5.43%). Significant predictors included sexual violence (frequency: 13.7%; AOR=2.2, 95% CI: 1.27–3.81, p=0.001), displacement (frequency: 41.1%; AOR=1.6, 95% CI: 1.10–2.32, p=0.043), frequent alcohol consumption (most frequent: 8.9%; AOR=2.1, 95% CI: 1.27–3.46, p=0.004), and limited ANC visits (frequency: 47.5%; AOR=1.8, 95% CI: 1.13–2.87, p=0.014). Conclusion & Recommendation: The high prevalence of HIV and syphilis co-infection rate underscores the need for targeted sexual violence prevention, improved ANC access, and integrated STI screening within ANC services in Mekelle City. Enhanced education on substance abuse and sexual health is essential.Item DETERMINANTS OF LATE INITIATION OF ANTENATAL CARE CONTACT AMONG PREGNANT WOMEN IN HEALTH FACILITIES OF MEKELLE, TIGRAY, NORTHERN ETHIOPIA, 2024(Mekelle University, 2025-02-25) GENET TESFAMICHAELBackground: Late antenatal care is the most common issue in developing countries, including Ethiopia. In Ethiopia, 72% of pregnant women come late for their first antenatal care contact. Late antenatal care initiation is more likely to be linked to poor perinatal health outcomes. Where the effects of late antenatal care initiation are significant in Ethiopia, a scarcity of data hinders for understanding of its determinants. Objective: To identify determinants of late initiation of antenatal care contact among pregnant women in health facilities of Mekelle, Tigray, Northern Ethiopia,2024. Method: Facility based unmatched case control study was conducted in health facilities of Mekelle, Tigray, Northern Ethiopia, from 7 August -5 September, 2024. The data were collected using pre-tested structured questionnaire. In this study 592 study participants (296 cases and 296 controls) were selected using systematic random sampling technique. Cases to controls ratio was 1 to 1. Bivariate and multivariable logistic regression analysis were used to identify determinants of late antenatal care initiation and adjusted odds ratio with corresponding 95% confidence interval was used to measure strength of association. Statistical significance was declared at 𝑃-value <0.05. Result: A total of 592 study participants were included in the study with 98% response rate. Low educational level [AOR=5.60;95%CI:2.766-11.357], recognizing pregnancy by missed period [AOR=2.552; 95%CI:1.588-4.102], unplanned pregnancy [AOR=3.216; 95%CI:1.934-5.347], not accompanied by their husband to ANC contact [AOR=4.306; 95%CI:2.757-6.726] and poor knowledge of the mothers about ANC [AOR=2.049; 95%CI: 1.326-3.168] were identified as determinants of late initiation of ANC among pregnant women. Conclusion and recommendation: Low educational level, recognizing pregnancy by missed period, unplanned pregnancy, not accompanied by their husband to ANC contact and poor knowledge of the mothers about ANC were identified as determinants of late initiation of ANC among pregnant women. Therefore, Health offices and healthcare providers should focus on increasing awareness to improve women's knowledge on ANC services, and to support spouse involvement in ANC.