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    JOINT MODELING OF TIME TO DEVELOP TUBERCULOSIS AND CHANGE IN CD4 COUNT AMONG HIV PATIENTS UNDER ART IN MEKELLE, ETHIOPIA, 2024
    (Mekelle University, 2025-06-28) TEKLEBRHAN KINFE
    Background: In patients with HIV, tuberculosis remains the leading cause of mortality and morbidity. Little is known about the predictors and the median time to develop tuberculosis while considering for the effect of the variation of longitudinal CD4 cell count. Objective: To investigate the time to develop tuberculosis accounting for longitudinal CD4 cell count change and its predictors among HIV patients who are under ART follow-up at Mekelle General Hospital and Ayder Comprehensive Specialized Hospital, Mekelle, Ethiopia, 2024. Methodology: A facility-based retrospective follow-up study was conducted among 449 adult PLHIV under ART follow-up from March 2018 to May 2024. The study participant were selected via a simple random sampling. The secondary data were collected from the patients’ medical records via Kobocollect version 2021.2.4 and exported to STATA version 17.0. The final model was a joint random intercept Cox-proportional hazard model. A model with the lowest Akaike information criterion and Bayesian information criterion was selected. Results: The incidence density of TB disease was 6.77 cases/100 person-years with a restricted mean survival time of 60 months. The joint analysis provided an association parameter alpha with AHR=0.854; 95% CI(0.8-0.91), indicating that for a unit increase in the average √CD4 cell count , the hazard of TB infection decreased by 14.6%, keeping other variables constant. The study also revealed that advanced WHO clinical stage (AHR = 1.024, 95% CI: 1.017–1.033), sex (AHR= 1.62, 95% CI: 1.09,2.4), CPT intake (AHR= 0.55, 95% CI: 0.35,0.89), and adherence (AHR= 0.38, 95% CI: 0.28,0.52) were significantly associated with the time to develop tuberculosis. The random intercept model indicated that greater variation in CD4 counts at baseline contributed strongly to the hazard of tuberculosis. Conclusion and Recommendation: This research highlights that PLHIV with a decreasing trajectory of CD4 count, advanced WHO clinical stage, female sex, history of CPT intake, and poor adherence have a higher risk of tuberculosis. On the basis of these findings, it is strongly recommended that the government and relevant health actors working on TB/HIV should intensify activities that improve patient adherence and a regular CD4 cell measurement.
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    Magnitude and Associated Factors of Oligohydramnios Among Third Trimester Pregnant Women Attending at Mekelle Public Hospitals, Tigray, Ethiopia: Institution-Based Cross Sectional Study
    (Mekelle University, 2025-06-28) SHUSHAY TEKULU
    Background: Oligohydramnios is a condition where amniotic fluid volume is lower than expected for gestational age. It is the most common amniotic fluid disorder and the leading cause of severe fetal and maternal adverse outcomes. Despite the severity of the problem, studies regarding the magnitude and associated factors of oligohydramnios in third-trimester pregnancy were limited in Ethiopia, mainly in the study area. Objective: To assess magnitude and associated factors of oligohydramnios among women in the third trimester of pregnancy at Mekelle public hospitals, Tigray, Ethiopia, 2024/2025. Methods: A cross-sectional study was conducted from December/1/2024 to May/30/2025 in Mekelle city. We included pregnant women using consecutive sampling technique using predefined inclusion criteria. Interview using structured questionnaire was employed to collect socioeconomic and demographic, lifestyle, medical and obstetric related data. The data were analyzed using SPSS version 27. Descriptive statistics were utilized to summarize data. Binary logistic regression analysis was employed to identify factors associated with oligohydramnios in third-trimester of pregnancy. Variables with P<0.05 in multi-variable analysis were declared statistically significant & interpreted using AOR with 95% CI. Hosmer-Lemeshow test was used to assess model fitness & it was insignificant (P=0.956), indicating a good-fitted model for the data. The maximum VIF was 1.12, telling that no Multicolinearity issue among covariates. Results: The mean age of the study participant, 356 with a 100% response rate, was a 28.2±5.06 years. The magnitude of oligohydramnios in third trimester of pregnancy was 7.9% (95% CI: 5.3-11.2%). Women with a history of diabetes mellitus [AOR=4.12 (95% CI: 1.26-13.53)], hypertension [AOR=6.12 (95% CI: 1.82-20.59)], anemia [AOR=4.63 (95% CI: 1.61-13.37)], hyperemesis gravid arum [AOR=4.76 (95% CI: 1.82-12.48)], post-term pregnancy [AOR=7.22 (95% CI: 1.41-36.98)] and fetal factors, including congenital anomalies [AOR=7.60 (95% CI: 1.81-31.94)] and intrauterine growth restriction [AOR=5.87 (95% CI: 1.42-24.32)], were significantly associated with an increased odds of oligohydramnios. Conclusion & Recommendations: 7.9% of pregnant women had sustained oligohydramnios. Maternal diabetes, hypertension, anemia, hyperemesis gravid arum, post-term pregnancy, fetal congenital anomalies and intrauterine growth restriction were identified as significant risk factors for oligohydramnios. We recommend increased surveillance for oligohydramnios focusing on the identified risks, maternal life style modifications & regular antenatal checkups in pregnancy.
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    Sero-prevalence of hepatitis B virus and human immunodeficiency virus, and associated factors among pregnant women attending antenatal care in selected general hospitals of Mekelle and Eastern zone of Tigray region, Northern Ethiopia
    (Mekelle University, 2025-06-28) SENAIT KEBEDE
    Background: Hepatitis B virus (HBV) and Human Immunodeficiency Virus (HIV) share common transmission risk factors and represent significant global public health challenges. They are major contributors to morbidity and mortality among pregnant women, especially in low and middle-income countries. However, there is limited local data on the burden of these infections among pregnant women in the study area collectively. Hence, this study was aimed to assess the sero-prevalence of hepatitis B viruses (HBV) and human immunodeficiency viruses (HIV), and associated factors among pregnant women attending antenatal care in selected general hospitals of Mekelle and Eastern Zone of Tigray, Northern Ethiopia. Method: A hospital based cross sectional study was conducted from December 2024 to April 2025 in selected general hospitals of Mekelle and Eastern zones of Tigray. Socio-demographic risk factors data and blood sample were collected from the 238 pregnant women. Rapid diagnostic tests were used to detect HBV and HIV. HBV confirmation with Enzyme linked immune sorbent assay (ELISA) was also performed. Data was entered and analyzed using SPSS version 27. Descriptive and Logistic regression analysis was used to assess associations between variables. A p-value of ≤0.05 was considered as statistical significant. Result: The overall seroprevalence of HBV and HIV were 9.7% and 4.2% respectively. However, no cases of HBV/HIV co-infection were identified. Among the three sites the seroprevalence of HBV and HIV were 8.9% & 3.7%, 8% & 2.7% and 11.9% & 6% in Adigrat, Wukro and Mekelle respectively. Variables like older age (AOR = 3.10, 95% CI: 1.01–9.46, P = 0.047), history of liver disease (AOR = 23.67, 95% CI: 3.55–158.01, P = 0.001), history of abortion (AOR: 0.23, 95% CI: 0.05-0.96; p=0.043), nose piercing (AOR: 4.01, 95% CI: 1.35, 11.92; p=0.013) and history of sexually transmitted infection(AOR: 5.94, 95% CI: 1.41-24.99; p=0.015) were revealed significant association with seroprevalence of HBV while knowledge about transmission of HIV (Exact OR = 0.10, 95% CI: 0.02–0.72, p = 0.0219) was the only variable significantly associated with of HIV infection. Conclusion: The overall seroprevalence of HBV among pregnant women attending antenatal care was high according to WHO classification. The current HIV prevalence lies within the range of the pooled HIV prevalence among pregnant women in Ethiopia
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    PREVALENCE OF CONGENITAL ANOMALIES AND ASSOCIATED FACTORS AMONG INFANTS OF DIABETIC MOTHERS DELIVERED IN TERTIARY HOSPITALS OF TIGRAY, ETHIOPIA: A CROSS-SECTIONAL STUDY
    (Mekelle University, 2025-06-28) DAWIT TSEGAY
    Background: Congenital anomalies, or CAs, are structural or functional abnormalities that arise during intrauterine development and can be identified at birth, later in infancy, or throughout fetal life. CAs affects approximately 3% of live births worldwide, and this rised sharply to 5– 14% among infants of diabetic mothers. CAs account for approximately 25% of infant deaths worldwide. Maternal diabetes, particularly when poorly managed during the peri-conceptional period, increases the risk of CAs through mechanisms such as oxidative stress and impaired cellular development. Despite the growing concern of CAs, has been no study on the prevalence and risk factors of congenital anomalies among infants of diabetic mothers in Tigray, Ethiopia. Objective: To assess the prevalence of congenital anomalies and associated factors among infants of diabetic mothers delivered in tertiary hospitals of Tigray, Ethiopia, Nov 2022 to Dec 2024. Methods: An institution- based retrospective cross-sectional study was conducted among 356 infants of diabetic mothers delivered at Ayder and Aksum referral hospitals between November 2022 and December 2024. The minimum sample size was 345, and all eligible infants of diabetic mothers were included. Pretesting, supervision, and training were used to control data quality. Data were collected using Kobo Toolbox and analyzed with STATA version 17. Binary logistic regression model was used and variables with p-values less than 0.25 in bivariate analysis were included in multivariable logistic regression with a 95% confidence interval. Model fitness (p value = 0.95) and Multicollinearity (VIF < 1.78) were assessed. Result: The prevalence of congenital anomalies among infants of diabetic mothers was 5.34% (95% CI: 3.24 - 8.21). Cardiovascular (42.1%) and central nervous system (31.6%) anomalies were the most common. Significant factors associated with congenital anomalies included high maternal blood glucose during pregnancy (AOR = 4.04; 95% CI: 1.36 –12.03), comorbidities in pregnancy (AOR = 3.87; 95% CI: 1.29 –11.58), prior unexplained fetal death (AOR = 3.03; 95% CI: 1.05 –8.74), and a history of macrosomic delivery (AOR = 3.78; 95% CI: 1.24 -11.49). Conclusion and Recommendation: Congenital anomalies (CAs) were present in 5.34% of infants of diabetic mothers. Congenital anomalies were significantly associated with high maternal blood glucose, comorbidities related to diabetes mellitus during pregnancy, previous stillbirth, and macrosomia. These finding emphasize the need for proactive comorbidity management, enhanced glycemic control, and comprehensive prenatal care for mothers with a history of stillbirth or macrosomia in order to decrease CAs in diabetic pregnancies. The study recommends that the underlying modifiable factors be prevented through better glycemic control during preconception and pregnancy, that oral glucose tolerance tests be used to strengthen universal diabetes screening, that special attention be given to DM mothers who have a history of macrosomic babies or stillbirths, and that comorbidities be taken seriously during pregnancy.
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    FERTILITY DESIRE AND ITS ASSOCIATED FACTORS AMONG WOMEN ATTENDING ANTIRETROVIRAL THERAPY AT PUBLIC HOSPITALS IN MEKELLE, TIGRAY, ETHIOPIA, 2024: CROSS SECTIONAL STUDY
    (Mekelle University, 2025-02-25) SOLOMON TEKLU
    Background: Fertility desire is defined as having motivation or intention to give birth by individuals in their future life irrespective the number of children. Fertility desire has undesirable effect on the transmission of human immunodeficiency virus to the partner due to unsafe sex, vertical transmission to the children and there will be also disagreement with the strategies developed for elimination of human immunodeficiency virus/acquired immunodeficiency syndrome in countries including Ethiopia. Objective: To assess the prevalence of fertility desire and its associated factors among women attending antiretroviral therapy at public hospitals in Mekelle, Tigray, Ethiopia, 2024. Methods and Materials: Institutional based cross-sectional study was conducted among 355 women and participants were selected using systematic random sampling method. The data were collected from August 1, 2024 to August 30, 2024 using pre-tested and interviewer administer questionnaire. Few variables were recorded from participant’s card. The data were analyzed using statistical package for social science version 27. Binary logistic regression method of analysis was used. All variables with P-value <0.25 in bivariate were included in the multivariable binary logistic regression analysis. The strength of the association was interpreted using an adjusted odds ratio with its 95% confidence interval. Statistically significant variable was declared at P-value < 0.05. Finally, the data were presented with texts, tables, figures, and graphs. Results: This study included 355 women, of them 345(97.2%) responded to the study. The prevalence of fertility desire was 182(52.8%, 95% CI: 46.6%-59.1%). Being single 69.3% (AOR: 0.307, 95% CI: O.111-0.84), being widowed 91% (AOR: 0.09, 95% CI: 0.038-0.214), being divorced 76.7% (AOR: 0.233, 95% CI: 0.109-0.497), number of women’s child 50.8% (AOR: 0.492, 95% CI: 0.382-0.632) and knowledge of women on prevention mother to child transmission 24.5% (AOR: 0.755, 95% CI: 0.608-0.938) were negatively associated with fertility desire. Conclusion and recommendation: This study revealed that more than half of participants had fertility desire and factors associated with it were marital status, number of women’s child, knowledge of the women on prevention mother to child transmission. All stakeholders should take into account the prevalence of fertility and its associated factors while serving the women living with human immunodeficiency virus and counsel the women to decrease their interest on the number of children and promote knowledge on the prevention of mother to child transmission.
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    MAGNITUDE AND ASSOCIATED FACTORS OF LOW BIRTH WEIGHT AMONG NEWBORNS DELIVERED IN PUBLIC HOSPITALS OF TIGRAY DURING CONFLICT TIME.
    (Mekelle University, 2025-06-21) SAMSON HADUSH
    Background: Birth weight is a critical determinant of perinatal survival and significantly influences infant morbidity and mortality. Low birth weight remains a serious global health issue, particularly in developing countries like Ethiopia, where research on low birth weight and its determinants is limited. This lack of data hampers efforts to address the underlying factors contributing to low birth weight and improve maternal and child health outcomes. The war in Tigray has disrupted healthcare services, potentially exacerbating the challenges associated with maternal health that leads low birth weights. Understanding the factors contributing to LBW will help to identify the impact of conflict on maternal and infant health and ensure that vulnerable populations receive the necessary support. Thus, the objective of this study aimed at identifying the magnitude and associated factors of LBW among newborns delivered at public health facilities in Tigray, Ethiopia Method: A Hospital based cross-sectional study design was applied from November 2024 – December 2024. A total of 540 newborn birth records were selected using systematic random sampling technique, and data was collected using data kobo tool. Six BSc degree holders were employed for data collection and the data collection period was entirely supervised by one masters’ degree holder and myself. Data was entered into Epi info 7, then exported to SPSS version 23. Binary logistic regression model was used to assess the associated factors of low birth weight. The results are presented as crude odds ratios (P<0.25) and adjusted odds ratios (AOR) (P<0.05) together with their corresponding 95% confidence intervals. Results: A total of 540 maternal cards were reviewed during the study period, with 95.8% rate of complete cards. In logistic regression model, significant association was found with Unplanned Pregnancy (AOR=10.4, 95% CI 5.10 - 21.26), No Antenatal care follow up (AOR=3.6, 95% CI 1.35 – 9.837), Gestational age <37 weeks (AOR=6.5, 95% CI 3.32 – 12.67), Obstetric complication (AOR=2.5, 95% CI 1.24 – 4.97), Medical complication (AOR=2.9, 95% CI 1.02 – 8.32), Maternal Anemia (AOR=3.3, 95% CI 2.37 – 46.49.26) and Acute malnutrition (AOR=2.8, 95% CI 1.31 – 9.94). Conclusion: The study finding indicated that a significant number of newborns measured low birthweight. The study identified factors such as pregnancy plan, ANC follow up, Obstetric and Medical condition during pregnancy, maternal acute malnutrition, Maternal Anemia and Gestational Age had significant association. Based on study findings, I recommend Tigray government and regional health bureau to make sure accessible health care system and advocating to nongovernmental organizations to support in recovering health care system which is destructed, Health care providers to counsel and provide comprehensive health care, particularly during pregnancy and before pregnancy.
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    MAGNITUDE AND ASSOCIATED FACTORS OF TB/HIV CO INFECTION AMONG HIV INFECTED PATIENTS ATTENDING IN MEKELLE PUBLIC HOSPITALS, TIGRAY, ETHIOPIA 2024/25
    (Mekelle University, 2025-05-21) KAHSU TSEGAY
    Introduction: -Tuberculosis is a contagious air born disease caused by Mycobacterium tuberculosis species and the leading causes of morbidity and mortality among people living with HIV/AIDS worldwide accounting for about 25% of all causes of the deaths. HIV infected clients are more susceptible to Tuberculosis infection. The World Health Organization Global Tuberculosis report of 2018 estimated that 10.0 million new cases of Tuberculosis occurred in 2017, of which over 82% of Tuberculosis deaths occurred in low- and middle-income countries. Evidence from this study helps to develop policies that address TB and HIV in an integrated, cost-effective manner and more efficient use of funds and resources. Objective: - The aim of this study was to assess the Magnitude and its associated factors of TB/ HIV co-infection among HIV infected patients in public hospitals of Mekelle, Tigray, Ethiopia 2025. Methods and materials: - Institutional based cross-sectional study was conducted and the period of data collection was from November to December 2024 G.C among ART patients. Systematic sampling technique was used to select 394 participants from the total source population. Data were collected using a pretested, interviewer, administered questionnaire and reviewing the medical record of the patient (CD4 cell count, hemoglobin level, BMI, WHO clinical stage, diagnosis of opportunistic infections, and TB). Data collection tool was pretested in 5% of total sample size in Wukro General Hospital. Data were coded and entered in to Epi data and was exported to statistical package for social science version 27 for statistical analysis. Descriptive statistics were performed. Both bivariate and multivariable logistic regression analyses were used to determine the association between independent variable and dependent variable. Variables having p value less than 0.25 in the bivariate analysis were exported in to multivariate logistic regression in multivariate logistic regression, p value <0.05 with 95% confidence interval (CI) was considered statistically significant. The Hosmer- Lemeshow goodness-of-fit model coefficients tests procedure was used to test for model fitting. Result – The magnitude of TB/ HIV co-infection was 18.8% and confidence interval (18.761 – 18.839). Marital status being widowed (AOR and 95% CI 0.238 (0.062, 0.903), hemoglobin level less than 11 (AOR and 95% CI 4.937 (1.884, 12.943), low CD4 count (200 cells mm3) (AOR and 95% CI 3.405 (1.174, 9.872), suspected TB patients in the household AOR and 95% CI 2.59 (1.026, 6.562) opportunistic infection without TB AOR and 95% CI (6.169 (2.272, 16.747), ambulatory AOR and 95% CI 22.906 (4.918,106.697), Bedridden AOR and 95% CI 11.436 (3.461, 37.79), poor drug adherence AOR and 95% CI 3.767 (1.389, 10.221), alcohol consumption AOR and 95% CI 15.129 (5.232, 43.748), raw/un cook foods consumption AOR and 95% CI 3.255 1.094, 9.682. were significant determinants of TB/HIV co-infection among HIV clients. Conclusion and recommendation The prevalence of tuberculosis among ART patients was high and this study indicated that marital status, hemoglobin level, CD4 count, presence of suspected TB patients in the household, presence of opportunistic infection without TB, functional status, drug adherence, alcohol consumption, utilization of raw/un cook foods were found significantly associated with TB/HIV co-infection. Providing counseling and health education regarding drug adherence, alcohol consumption and chat chewing to ART patients, and government should give priority on TB/ HIV confection.
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    DETERMINANTS OF SUCCESSFUL VAGINAL BIRTH AMONG MOTHERS WITH ONE PREVIOUS CAESAREAN SECTION IN PUBLIC HOSPITALS MEKELLE, TIGRAY, ETHIOPIA 2024: CASE CONTROL STUDY
    (Mekelle University, 2025-01-28) HADIS DERBEW
    Background: The World Health Organization says that 10-15% of babies should be born by C-section in hospitals. But in many countries, including Ethiopia, more babies are born by Csection. This can have bad effects on health and the economy. Having a vaginal birth after a previous C-section (VBAC) is usually safe and a good way to have fewer C-sections. Even though VBAC is successful 60-80% of the time, fewer mothers are trying to have a vaginal birth after a previous C-section, and the number of C-sections is going up. In Tigray have not been studied using case control study approaches on determinants of successful VBAC. So, this study aimed to identify determinants of successful VBAC at public hospitals in Mekelle town. Objective: To assess determinants of successful vaginal birth among women with one previous caesarean delivery in Mekelle public hospitals in 2024. Methods: Institutional based unmatched case control study was conducted in Mekelle public Hospitals from August 1, - September 30, 2024. A total of 194 study participants were included, of which 65 were cases and 129 were controls with cases to controls ratio of 1: 2. Systematic random sampling for controls and cases were selected consecutively. Data were collected using a structured and pre-tested questionnaire then data was entered to Epidata version 4.7 to be cleaned and coded, and exported to statistical package for social science version 27 for analysis. Bivariate, followed by multivariate analysis, were conducted with 95% CI and p-value <0.05 to identify factors associated with successful vaginal birth after cesarean delivery. Result: urban residence (AOR = 2.50, 95%CI: 1.13-5.55), history of SVD (AOR= 2.47, 95%CI: 1.10-5.51), cervical dilatation at admission > 4 cm (AOR = 2.36, 95%CI: 1.01-534), occiputo- anterior position (AOR = 9.69, 95%CI: 2.15-5.55) were determinants significantly associated with successful vaginal birth after previous cesarean section. Conclusion and recommendation: The study shows that urban residence, history of SVD, cervical dilatation at admission > 4 cm, occiputo- anterior position were associated with successful vaginal birth after previous cesarean section. Women live in rural area and cervical dilatation <4 cm at admission health care provider encourage, create awareness and counseled to delivery virginally after c/s. Women with a history of cesarean section should be counseled and encouraged to delivery vaginally as it is not contraindicated.
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    TREATMENT OUTCOME AND ASSOCIATED FACTORS AMONG UNDER-FIVE CHILDREN WITH SEVERE ACUTE MALNUTRITION WHO ARE ADMITTED IN STABILIZATION CENTER OF PUBLIC HOSPITALS, IN EASTERN ZONE OF TIGRAY, ETHIOPIA, 2024.
    (Mekelle University, 2025-01-28) HAGOS MEHARI
    Background: Globally, it is estimated that there are nearly 20 million children who are severely acutely malnourished. Undernutrition accounts for 45% of child mortality under the age of five, stunting still affects more than 5.4 million Ethiopian children. Researches are limited on treatment outcomes among sever acute malnutrition children in Tigray, Therefore, this study has the potential to fill this gap by providing evidences on treatment outcomes and associated factors among under-five children admitted in a stabilization center. Objective: The aim of the study is to assess treatment outcome and associated factors among children under-five with severe acute malnutrition who are admitted in a stabilization center, in public hospital in eastern zone of Tigray region 2024. Methods: A health facility-based cross-sectional study was done in 6 public hospitals of eastern zone of Tigray. The total sample size was 347 which were proportionally allocated for each hospital based on the estimated monthly case admission and participants were selected from each hospital using simple random sampling method. A pretest was done on 5% of the sample size in Kuiha hospital. In the Bivariate analysis variables with p-value < 0.25 were a candidate for the multivariable logistic regression analysis and statistical significance was declared at a p-value of <0.05. Result: Among 347 children, 70.3%, 19%, 6.3% and 4.6% of the cases were cured, died, transferred out and defaulters respectively. Children with better appetite upon admission (AOR = 3.849, 95% CI: 1.183–12.523), higher admission weight (AOR = 3.998, 95% CI: 2.022, 7.908), greater weight gain during treatment (AOR = 1.601, 95% CI: 1.096–2.339) and longer hospital stays (AOR = 1.222, 95% CI: 1.021–1.463) were associated with good treatment outcome. Conversely, the presence of fever at admission (AOR = 0.343, 95% CI: 0.152–0.772) was negatively associated with treatment success. Conclusions and Recommendations: Appetite upon admission, admission weight, fever, weight gain, and length of stay were significantly associated with treatment outcome. Based on these findings, it is recommended that healthcare facilities enhance nutritional support programs, manage fever and infections promptly, and monitor weight gain during hospitalization.
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    Magnitude and Determinants of Maternal Complications during Pregnancy and Post-Partum in Ethiopia: A Survey Study using PMA Data
    (Mekelle University, 2025-06-17) MAEDOT FISHA
    Background: A maternal complication is a physical or mental issue that affects the mother's health, the fetus's health, or both. Even women who were healthy before getting pregnant can experience complications. These complications may make the pregnancy a high-risk pregnancy. All pregnancies are at risk. According WHO (world health organization) most of the complications develop during pregnancy and most are preventable or treatable. Other complications may exist before pregnancy but are worsened during pregnancy. In Ethiopia the these complications were the major direct obstetric complications Objective: To determine the magnitude and determinant factors during pregnancy and postpartum complications data from PMA Ethiopia Methods: Performance Monitoring for action (PMA) surveys are a prospective cohort survey based on a multistage stratified cluster sampling design with urban-rural stratification. The sample size of this study is 1678 and the study population was women’s who have pregnant or women 0-4 weeks of postpartum. The magnitude of complications during pregnancy and postpartum period will be computed by using STATA 17 software. Multivariable logistic regression analysis was used to control confounding variables at the p-value < 0.05 and the strength of the statistical association with maternal complication during pregnancy and post partum was measured by using adjusted odds ratios and ` 95% confidence intervals. Result: magnitude of maternal complication during pregnancy and postpartum is 37.31% and38.74% respectively. Women who have develop a complication both during pregnancy and post partum were 18.3%. Women who have completed the higher education [AOR =0.191, 95% CI: (0.093, 0.392)]. A woman who has a grand multi Para [(AOR = 0.662, 95 % CI: (0.442, 0.993)]. Women’s who have obtain ANC follow up[AOR =0.758, 95% CI: (0.573, 1.004)]. Women with twin pregnancies [(AOR = 1.97, 95 % CI: (0.974, 3.963)] these factors associated with maternal complication during pregnancy. Living with a man [AOR = 2.453, 95% CI: (1.214, 4.957)]. Women who attended greater than 4 ANC follow up [AOR = 0.727, 95% CI: (0.526, 1.006)]. Women with twin pregnancy [AOR = 3.596, 95% CI: (1.225, 10.556)]. Postpartum visit [AOR = 0.682, 95% CI: (0.482, 0.965)] these factors associated with postpartum complication. Conclusion: Maternal complication during pregnancy and postpartum in Ethiopia was found to be major maternal health issue. Being living with a man, uneducated mother and their life partners, twin pregnancy, absence of post natal visit and low ANC visit were important predictors of maternal complications during pregnancy and postpartum period. By implementing targeted interventions to address the identified maternal complications, focusing on high - risk areas and populations to improve maternal health outcomes.