Department of Medical Biochemistry and Molecular Biology
Permanent URI for this collectionhttps://repository.mu.edu.et/handle/123456789/160
Browse
1 results
Search Results
Item Assessment of serum lipid profile in chronic kidney disease patients at Ayder Comprehensive Specialized Hospital,2024/2025(Mekelle University, 2025-08-25) YEMANE TEKLEHAYMANOTBackground: Chronic Kidney Disease (CKD) is a major public health problem worldwide with increasing incidence and prevalence with antecedent high medical cost and poor outcome. Dyslipidemia is a common complication in CKD patients and is associated with the decline of kidney function. There is a paucity of data in Ethiopia, particularly in Tigray region, regarding the pattern and progression of lipid profile abnormalities in CKD patients. Objective: To assess serum lipid profile in chronic kidney disease patients at Ayder Comprehensive Specialized Hospital, Tigray, Ethiopia, 2025. Methods: Comparative cross-sectional study design was carried out on 41 CKD patients and 41 age and sex matched controls, at Ayder Comprehensive Specialized Hospital from January 2025 to March 2025. Fasting blood samples were collected for the estimation of lipid profiles. Data was entered using Epi-data software version 4.7 and exported to SPSS software version 27 for analysis. Variables with P-value < 0.05 were considered statistically significant. Independent t-test was used to determine the lipid profile result of CKD patients in comparison to controls. A one-way ANOVA was used to identify the variation of lipid profiles across CKD stages. Correlation was used to determine the strength of association between the e-GFR and the lipid profiles. Estimated Glomerular Filtration Rate was calculated using CKD-EPI 2021 equation. Results: Total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL c) levels were significantly higher and high density lipoprotein-cholesterol (HDL-c) level was significantly lower in CKD patients than in controls. As CKD progressed from stage 1 to stage 4; TC, TG and LDL-c levels increase significantly and HDL-c decrease significantly. There was a significant negative correlation of e-GFR with TC, TG, LDL-c and a significant positive correlation with HDL-c. Conclusions: There was dyslipidemia in CKD patients characterized by elevated level of TC, TG, LDL-c and reduced HDL-c level. As CKD progressed from stage 1 to stage 4, there was a progressive increase in TC, TG, LDL-c and a progressive decrease in HDL-c and there was a significant correlation of e-GFR with lipid profiles. Early diagnosis and management of dyslipidemia in CKD patients is important for positive outcome.