College of Veterinary Sciences

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    EFFECT OF MIDAZOLAM AND ACEPROMAZINE WITH KETAMINE COMBINATION ON CLINICO-PHYSIOLOGICAL AND HEMATOBIOCHEMICAL PARAMETERS IN SHEEP IN MEKELLE, TIGRAY, ETHIOPIA
    (Mekelle University, 2023-11-25) HAILAY KAHSAY
    An experimental study was carried out from July to October 2023 to evaluate the effects of the general anesthetic combinations of Midazolam-Ketamine and AcepromazineKetamine on clinico-physiological and hematobiochemical parameters in sheep in Mekelle, Tigray, Ethiopia. Eight sheep were used in this experimental study. The sheep were randomly divided into two groups with four sheep each (two male and two female), of which four sheep were randomly assigned to an induction regimen of MidazolamKetamine (Group MK) and the other four sheep were assigned to AcepromazineKetamine (Group AK). Physical recording and laboratory analysis were used to collect the data. The collected data included anesthetic indices, physiological, hematobiochemical, and adverse effects of the anesthetic combinations. All recorded data were entered into a Microsoft Excel spreadsheet and analyzed with SPSS version 23.0. A paired t-test was used to compare the clinico-physiological and hematobiochemical measurements. The significant difference in mean values at a 95% confidence interval (CI) was assessed using an independent t-test. To pinpoint the combinations' negative impacts, the Fisher’s exact test was used. In this study, Acepromazine-Ketamine combination had a shorter sternal recumbency time (4.17 ± 0.64 min) and induction of anesthesia (7.85 ± 3.73 min). In contrast, the Midazolam-Ketamine combination had a longer induction of anesthesia (15.10 ± 4.28 min) and sternal recumbency time (5.53 ± 0.22 min). The duration of anesthesia (43.3 ± 1.12 min) and recovery period (49.89 ± 5.10 min) were longer in the Midazolam-Ketamine combination, whereas the duration of anesthesia (17.01 ± 6.27 min) and recovery period (33.61±5.92 min) was shorter in the Acepromazine-Ketamine combination. Following administration of the MidazolamKetamine combination, the respiratory rate and the heart rate increased significantly. The experiment showed that the combination of Acepromazine-Ketamine produced stable surgical anesthesia for a short duration, whereas the Midazolam-Ketamine combination was the choice of general anesthesia for a longer duration